| 57. | Ju Y, Janga SR, Klinngam W, MacKay JA, Hawley D, Zoukhri D, Edman MC, Hamm-Alvarez SF. NOD and NOR mice exhibit comparable development of lacrimal gland secretory dysfunction but NOD mice have more severe autoimmune dacryoadenitis. Exp Eye Res. 2018 Nov;176:243-251.
  PMID30201519 |  |
| 56. | Li Z, Tyrpak D, Park M, Okamoto CT, MacKay JA. A new temperature-dependent strategy to modulate the epidermal growth factor receptor. Biomaterials. 2018 Nov;183:319-330. PMID30196151 | |
| 55. | Guo H, Lee C, Shah M, Janga SR, Edman MC, Klinngam W, Hamm-Alvarez SF, MacKay JA. A novel elastin-like polypeptide drug carrier for cyclosporine A improves tear flow in a mouse model of Sjögren's syndrome. J Control Release. 2018 Oct 22. pii: S0168-3659(18)30605-9. PMID30359668 | |
| 54. | Peddi S, Pan X, MacKay JA. Intracellular Delivery of Rapamycin from FKBP Elastin-like Polypeptides is Consistent with Macropinocytosis. Front Pharmacol. Accepted 2018 Sept 28. | |
| 53. | Li Z, Tyrpak DR, Lien C, MacKay JA. Tunable Assembly of Protein-Microdomains in Living Vertebrate Embryos. Adv Biosyst. 2018 Sept 10. | |
| 52. | Sreekumar PG, Li Z, Wang W, Spee C, Hinton DR, Kannan R, MacKay JA. Intra-vitreal alphaB crystallin fused to elastin-like polypeptide provides neuroprotection in a mouse model of age-related macular degeneration. J Control Release. 2018 May 18;283:94-104. PMID29778783 | |
| 51. | Dhandhukia JP, Shi P, Peddi S, Li Z, Aluri SR, Ju Y, Brill D, Wang W, Janib S, Lin Y, Liu S, Cui H, and MacKay JA. Bi-functional elastin-like polypeptide nanoparticles bind rapamycin and integrins, and suppress tumor growth in vivo. Bioconjug Chem. 2017 Nov 15;28(11):2715-2728. PMC5779105 | |
| 50. | Dhandhukia JP, Brill DA, Kouhi A, Pastuszka MK, MacKay JA. Elastin-like polypeptide switches: A design strategy to detect multimeric proteins. Protein Sci. 2017 Sep;26(9):1785-1795. PMC5563140 | |
| 49. | Dhandhukia JP, Li Z, Peddi S, Kakan S, Mehta A, Tyrpak D, Despanie J, MacKay JA. Berunda Polypeptides: Multi-Headed Fusion Proteins Promote Subcutaneous Administration of Rapamycin to Breast Cancer In Vivo. Theranostics. 2017 Aug 29;7(16):3856-3872. PMC5667409 | |
| 48. | Shah M, Edman MC, Janga SR, Yarber F, Meng Z, Klinngam W, Bushman J, Ma T, Liu S, Louie S, Mehta A, Ding C, MacKay JA, Hamm-Alvarez SF. Rapamycin eye drops suppress lacrimal gland inflammation in a murine model of Sjögren’s Syndrome. Invest Ophthalmol Vis Sci. 2017 Jan; 58(1): 372-385. PMC5270623 | |
| 47. | Despanie J, Dhandhukia J, Hamm-Alvarez SF, MacKay JA. Elastin-like polypeptides: Therapeutic applications for an emerging class of nanomedicines. J Control Release. 2016 Oct 28;240:93-108. (peer-reviewed). PMID26578439 | |
| 46. | Brill DA, MacKay JA. Image-Driven Pharmacokinetics: Nanomedicine Concentration Across Space and Time. Nanomedicine (Lond). 2015;10(18):2861-79 (peer-reviewed). PMID26370694 | |
| 45. | Hsueh PY, Edman MC, Sun G, Shi P, Xu S, Lin Y-A, Cui H, Hamm-Alvarez SF, MacKay JA. Tear-mediated delivery of nanoparticles through transcytosis of the lacrimal gland. J Cont Rel. 2015 Jun 28;208:2-13. PMC4456098 | |
| 44. | Pastuszka MK, MacKay JA. Engineering structure and function using thermoresponsive biopolymers. WIREs Nanomedicine & Nanobiotechnology. 2015 Jun 26 (peer-reviewed). PMID26112277 | |
| 43. | Wang W, Jashnani A, Aluri SR, Gustafson JA, Hsueh PY, Yarber F, McKown RL, Laurie GW, Hamm-Alvarez SF, MacKay JA. A thermo-responsive protein treatment for dry eyes. J Cont Rel. 2015 Feb 10;199:156-67. PMC4456095 | |
| 42. | Wang W, Despanie J, Shi P, Edman-Woolcott MC, Lin Y-A, Cui H, J. Heur M, Fini E, Hamm-Alvarez SF, MacKay JA. Lacritin-mediated regeneration of the corneal epithelia by protein polymer nanoparticles. J Mater Chem B. 2014 Dec 14;2(46):8131-8141. Featured on inside front cover. PMC4270104 | |
| 41. | Wang W, Sreekumar PG, Valluripalli V, Shi P, Wang J, Lin Yi-An, Cui H, Kannan R, Hinton DR, MacKay JA. Protein polymer nanoparticles engineered as chaperones protect against apoptosis in human retinal pigment epithelial cells. J Cont Rel. 2014 Oct 10;191:4-14. PMC4222838 | |
| 40. | Pastuszka MK, Wang X, Lock LL, Janib SM, Cui H, DeLeve LD, MacKay JA. An amphipathic alpha-helical peptide from apolipoprotein A1 stabilizes protein polymer vesicles. J Cont Rel. 2014 Oct 10;191:15-23. PMC4327866 | |
| 39. | Pastuszka MK, Okamoto CT, Hamm-Alvarez SF, MacKay JA. Flipping the Switch on Clathrin-Mediated Endocytosis using Thermally Responsive Protein Microdomains. Adv Func Mater. 2014 Sep 10;24(34):5340-5347. Featured on issue cover. PMC4235962 | |
| 38. | Janib SM, Gustafson, JA, Minea RO, Swenson SD, Liu S, Pastuszka MK, Lock LL, Cui H, Markland FS, Conti PS, Li Z, MacKay JA. Multimeric disintegrin protein polymer fusions that target tumor vasculature. Biomacromolecules. 2014 Jul 14;15(7):2347-58. PMC4098058 | |
| 37. | Aluri S, Shi P, Gustafson J, Wang W, Lin YA, Cui H, Liu S, Conti PS, Li Z, Hu P, Epstein AL, MacKay JA. A Hybrid Protein-Polymer Nanoworm Potentiates Apoptosis Better Than a Monoclonal Antibody. ACS Nano. 2014 Mar 25;8(3):2064-76. PMC4004287 | |
| 36. | Shi P, Gustafson JA, MacKay JA. Genetically engineered nanocarriers for drug delivery. Int. J. Nanomedicine. 2014 Mar 26;9:1617-26 (peer-reviewed). PMC3970941 | |
| 35. | Janib SM, Pastuszka MK, Aluri SR, Folchman-Wagner Z, Hsueh P, Shi P, Lin YA, Cui H, MacKay JA. A quantitative recipe for engineering protein polymer nanoparticles. Polym Chem. 2014 Jan;5(5):1614-1625. PMC3916011 | |
| 34. | Shi P, Lin YA, Pastuszka M, Cui H, MacKay JA. Triggered Sorting and Co-Assembly of Genetically Engineered Protein Microdomains in the Cytoplasm. Adv Mater. 2014 Jan 22;26(3):449-54. PMC3947098 | |
| 33. | Shi P, Aluri SR, Lin YA, Shah M, Edman-Woolcott M, Dhandhukia J, Cui H, MacKay JA. Elastin-based protein polymer nanoparticles carrying drug at both corona and core suppress tumor growth in vivo. J Cont Rel. 2013 Nov 10;171(3):330-8. PMC3795821 | |
| 32. | Shah M, Edman MC, Janga SR, Shi P, Dhandhukia J, Liu S, Louie SG, Rodgers K, MacKay JA, Hamm-Alvarez SF. A rapamycin-binding protein polymer nanoparticle shows potent therapeutic activity in suppressing autoimmune dacryoadenitis in a mouse model of Sjögren's syndrome. J Cont Rel. 2013 Nov 10;171(3):269-79. PMC3796004 | |
| 31. | Dhandhukia J, Weitzhandler I, Wang W, MacKay JA. Switchable Elastin-Like Polypeptides that Respond to Chemical Inducers of Dimerization. Biomacromolecules. 2013 Apr 8; 14(4):976-85. PMC3721738 | |
| 30. | Janib SM, Liu S, Park R, Pastuszka MK, Shi P, Moses A, Orosco M, Lin YA, Cui H, Conti P, Li Z, MacKay JA. Kinetic quantification of protein polymer nanoparticles using non-invasive imaging. Integr Biol. 2013 Jan; 5(1):183-94. PMC3762326 | |
| 29. | Pastuszka MK, Janib SM, Weitzhandler I, Okamoto CT, Hamm-Alvarez SF, MacKay JA. A tunable and reversible platform for the intracellular formation of genetically engineered protein microdomains. Biomacromolecules. 2012 Nov 12; 13(11):3439-44. PMC3500625 | |
| 28. | Aluri SR, Pastuszka MK, Moses AS, MacKay JA. Elastin-like Peptide-Amphiphiles form nanofibers with tunable length. Biomacromolecules. 2012 Sep 10;13(9):2645-54. PMC3461336 | |
| 27. | Shah M, Hsueh PY, Sun G, Chang HY, Janib SM, MacKay JA. Biodegradation of elastin-like polypeptide nanoparticles. Protein Sci. 2012 Jun;21(6):743-50. PMC3403411 | |
| 26. | Sun G, Hsueh P, Janib S, Hamm-Alvarez SF, MacKay JA. Design and cellular internalization of genetically engineered polypeptide nanoparticles displaying adenovirus knob domain. J Cont Rel. 2011 Oct 30; 155(2):218-26. PMC3196066 | |
| 25. | Chen M, McDaniel JR, MacKay JA, Chilkoti, A. Nanoscale Self-Assembly for Delivery of Therapeutics and Imaging Agents. Technol Innov. 2011 Jan 1;13(1):5-25 (peer-reviewed). PMC3784687 |  |
| 24. | MacKay JA, Callahan DJ, FitzGerald KN, Chilkoti A. A quantitative model of the phase behavior of recombinant pH-responsive protein polymers. Biomacromolecules. 2010 Oct; 11(11): 2873-9. PMC3032028 | |
| 23. | Janib SM, Moses AS, MacKay JA. Imaging and drug delivery using theranostic nanoparticles. Adv Drug Deliv Rev. 2010 Aug 30;62(11):1052-63 (peer-reviewed). PMC3769170 | |
| 22. | Liu W, MacKay JA, Dreher MR, Chen M, McDaniel JR, Simnick AJ, Callahan DJ, Zalutsky MR and Chilkoti A. Injectable intratumoral depot of thermally responsive polypeptide-radionuclide conjugates delays tumor progression in a mouse model. J Cont Rel. 2010 May 21;144(1):2-9. PMC2862899 | |
| 21. | Pastuszka MK, MacKay JA. Biomolecular engineering of intracellular switches in eukaryotes. J Drug Deliv Sci Technol. 2010 May;20(3):163-169 (peer-reviewed). PMC3013508 | |
| 20. | McDaniel J, MacKay JA, Quiroz F, Chilkoti, A. Recursive Directional Ligation by Plasmid Reconstruction allows Rapid and Seamless Cloning of Oligomeric Genes. Biomacromolecules. 2010 Apr 12;11(4):944-52. PMC2862688 | |
| 19. | Co-editor, with Zibo Li, Advanced Drug Delivery Reviews issue entitled “Development of theranostic agents that co-deliver therapeutic and imaging agents”, 62(11) 2010. | |
| 18. | MacKay JA, Chen M, McDaniel JR, Liu W, Simnick AJ, Chilkoti A. Self-assembling chimeric polypeptide-doxorubicin conjugate nanoparticles that abolish tumors after a single injection. Nat Mater. 2009 Dec;8(12):993-9. PMC2862348 | |
| 17. | Gao W, Liu W, MacKay JA, Zalutsky M, Toone E, Chilkoti A. In situ growth of a stoichiometric PEG-like conjugate at a protein’s N-terminus with significantly improved pharmacokinetics. Proc Natl Acad Sci U S A. 2009 Sep 8;106(36):15231-6. PMID19706892 | |
| 16. | Aluri S, Janib SM, MacKay JA. Environmentally responsive peptides as anticancer drug carriers. Adv Drug Deliv Rev. 2009 Sep 30;61(11):940-52 (peer-reviewed). PMC2757494 | |
| 15. | Wu Y, MacKay JA, McDaniel JR, Chilkoti A, Clark RL. Fabrication of Elastin-Like Polypeptide Nanoparticles for Drug Delivery by Electrospraying. Biomacromolecules. 2009 Jan 12;10(1):19-24. PMID19072041 | |
| 14. | MacKay JA, Chilkoti A. Temperature sensitive peptides: engineering hyperthermia-directed therapeutics. Int J Hyperthermia. 2008 Sep;24(6):483-95 (peer-reviewed). PMID18608590 | |
| 13. | MacKay JA, Li W, Huang Z, Huynh G, Dy E, Tihan T, Collins R, Deen DF, Szoka FC Jr. HIV TAT peptide modifies the distribution of liposomes, DNA nanolipoparticles, and transfection following convection enhanced delivery. Mol Ther. 2008 May;16(5):893-900. PMID18388927 |  |
| 12. | Lim DW, Trabbic-Carlson K, MacKay JA, Chilkoti A. Improved non-chromatographic purification of a recombinant protein by cationic elastin-like polypeptides. Biomacromolecules. 2007 May;8(5):1417-24. PMID17407348 | |
| 11. | Chilkoti A, Christensen T, MacKay JA. Stimulus responsive elastin biopolymers: Applications in medicine and biotechnology. Curr Opin Chem Biol. 2006 Dec;10(6):652-7 (peer-reviewed). PMID17055770 | |
| 10. | Huang Z, Guo X, Li W, MacKay JA, Szoka FC Jr. Acid-triggered transformation of diortho ester phosphocholine liposome. J Am Chem Soc. 2006 Jan 11;128(1):60-1. PMID16390121 | |
| 9. | Lee CC, MacKay JA, Frechet JM, Szoka FC. Designing dendrimers for biological applications. Nat Biotechnol. 2005 Dec;23(12):1517-26 (peer-reviewed). PMID16333296 | |
| 8. | Huang Z, Li W, Mackay JA, Szoka FC Jr. Thiocholesterol-based lipids for ordered assembly of bioresponsive gene carriers. Mol Ther. 2005 Mar;11(3):409-17. PMID15727937 | |
| 7. | Krylova IN, Sablin EP, Moore J, Xu RX, Waitt GM, MacKay JA, Juzumiene D, Bynum JM, Madauss K, Montana V, Lebedeva L, Suzawa M, Williams JD, Williams SP, Guy RK, Thornton JW, Fletterick RJ, Willson TM, Ingraham HA. Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1. Cell. 2005 Feb 11;120(3):343-55. PMID15707893 | |
| 6. | MacKay JA, Deen DF, Szoka FC Jr. Distribution in brain of liposomes after convection enhanced delivery; modulation by particle charge, particle diameter, and presence of steric coating. Brain Res. 2005 Feb 28;1035(2):139-53, cover. PMID15722054 | |
| 5. | Li W, Huang Z, MacKay JA, Grube S, Szoka FC Jr. Low-pH-sensitive poly(ethylene glycol) (PEG)-stabilized plasmid nanolipoparticles: effects of PEG chain length, lipid composition and assembly conditions on gene delivery. J Gene Med. 2005 Jan;7(1):67-79. PMID15515149 | |
| 4. | Guo X, MacKay JA, Szoka FC Jr. Mechanism of pH-triggered collapse of phosphatidylethanolamine liposomes stabilized by an ortho ester polyethyleneglycol lipid. Biophys J. 2003 Mar;84(3):1784-95. PMC1302747 | |
| 3. | Choi JS, MacKay JA, Szoka FC Jr. Low-pH-sensitive PEG-stabilized plasmid-lipid nanoparticles: preparation and characterization. Bioconjug Chem. 2003 Mar-Apr;14(2):420-9. PMID12643753 | |
| 2. | MacKay JA, Szoka FC Jr. HIV TAT protein transduction domain mediated cell binding and intracellular delivery of nanoparticles. J Disp Sci Tech. 2003 (peer-reviewed). 24(3-4): 467-73. PMID20808712 | |
| 1. | Martin I, Shastri VP, Padera RF, Yang J, MacKay JA, Langer R, Vunjak-Novakovic G, Freed LE. Selective differentiation of mammalian bone marrow stromal cells cultured on three-dimensional polymer foams. J Biomed Mater Res. 2001 May;55(2):229-35. PMID11255174 |  |
