PUBLICATIONS


51.Dhandhukia JP, Shi P, Peddi S, Li Z, Aluri SR, Ju Y, Brill D, Wang W, Janib S, Lin Y, Liu S, Cui H, and MacKay JA. Bi-functional elastin-like polypeptide nanoparticles bind rapamycin and integrins, and suppress tumor growth in vivo. Bioconjugate Chem. 2017 Sept. DOI: 10.1021/acs.bioconjchem.7b00469. Journal USC
50.Dhandhukia JP, Li Z, Peddi S, Kakan S, Mehta A, Tyrpak D, Despanie J, MacKay JA. Berunda Polypeptides: Multi-Headed Fusion Proteins Promote Subcutaneous Administration of Rapamycin to Breast Cancer In Vivo. Theranostics 2017; 7(16):3856-3872. Journal USC
49.Dhandhukia JP, Brill DA, Kouhi A, Pastuszka MK, MacKay JA. Elastin-like polypeptide switches: A design strategy to detect multimeric proteins. Protein Sci. 2017 Sep;26(9):1785-1795. PubMed PMID28639381USC
48.Shah M, Edman MC, Janga SR, Yarber F, Meng Z, Klinngam W, Bushman J, Ma T, Liu S, Louie S, Mehta A, Ding C, MacKay JA, Hamm-Alvarez SF. Rapamycin eye drops suppress lacrimal gland inflammation in a murine model of Sjögren’s Syndrome. Invest Ophthalmol Vis Sci. 2017 Jan; 58(1): 372-385. PubMed PMC5270623USC
47.Despanie J, Dhandhukia J, Hamm-Alvarez SF, MacKay JA. Elastin-like polypeptides: Therapeutic applications for an emerging class of nanomedicines. J Control Release. 2016 Oct 28;240:93-108. (peer-reviewed). PubMed PMID26578439USC
46.Brill DA, MacKay JA. Image-Driven Pharmacokinetics: Nanomedicine Concentration Across Space and Time. Nanomedicine (Lond). 2015;10(18):2861-79 (peer-reviewed). PubMed PMID26370694USC
45.Hsueh PY, Edman MC, Sun G, Shi P, Xu S, Lin Y-A, Cui H, Hamm-Alvarez SF, MacKay JA. Tear-mediated delivery of nanoparticles through transcytosis of the lacrimal gland. J Cont Rel. 2015 Jun 28;208:2-13. PubMed PMC4456098USC
44.Pastuszka MK, MacKay JA. Engineering structure and function using thermoresponsive biopolymers. WIREs Nanomedicine & Nanobiotechnology. 2015 Jun 26 (peer-reviewed). PubMed PMID26112277USC
43.Wang W, Jashnani A, Aluri SR, Gustafson JA, Hsueh PY, Yarber F, McKown RL, Laurie GW, Hamm-Alvarez SF, MacKay JA. A thermo-responsive protein treatment for dry eyes. J Cont Rel. 2015 Feb 10;199:156-67. PubMed PMC4456095USC
42.Wang W, Despanie J, Shi P, Edman-Woolcott MC, Lin Y-A, Cui H, J. Heur M, Fini E, Hamm-Alvarez SF, MacKay JA. Lacritin-mediated regeneration of the corneal epithelia by protein polymer nanoparticles. J Mater Chem B. 2014 Dec 14;2(46):8131-8141. Featured on inside front cover. PubMed PMC4270104USC
41.Wang W, Sreekumar PG, Valluripalli V, Shi P, Wang J, Lin Yi-An, Cui H, Kannan R, Hinton DR, MacKay JA. Protein polymer nanoparticles engineered as chaperones protect against apoptosis in human retinal pigment epithelial cells. J Cont Rel. 2014 Oct 10;191:4-14. PubMed PMC4222838USC
40. Pastuszka MK, Wang X, Lock LL, Janib SM, Cui H, DeLeve LD, MacKay JA. An amphipathic alpha-helical peptide from apolipoprotein A1 stabilizes protein polymer vesicles. J Cont Rel. 2014 Oct 10;191:15-23. PubMed PMC4327866USC
39.Pastuszka MK, Okamoto CT, Hamm-Alvarez SF, MacKay JA. Flipping the Switch on Clathrin-Mediated Endocytosis using Thermally Responsive Protein Microdomains. Adv Func Mater. 2014 Sep 10;24(34):5340-5347. Featured on issue cover. PubMed PMC4235962USC
38.Janib SM, Gustafson, JA, Minea RO, Swenson SD, Liu S, Pastuszka MK, Lock LL, Cui H, Markland FS, Conti PS, Li Z, MacKay JA. Multimeric disintegrin protein polymer fusions that target tumor vasculature. Biomacromolecules. 2014 Jul 14;15(7):2347-58. PubMed PMC4098058USC
37.Aluri S, Shi P, Gustafson J, Wang W, Lin YA, Cui H, Liu S, Conti PS, Li Z, Hu P, Epstein AL, MacKay JA. A Hybrid Protein-Polymer Nanoworm Potentiates Apoptosis Better Than a Monoclonal Antibody. ACS Nano. 2014 Mar 25;8(3):2064-76. PubMed PMC4004287USC
36.Shi P, Gustafson JA, MacKay JA. Genetically engineered nanocarriers for drug delivery. Int. J. Nanomedicine. 2014 Mar 26;9:1617-26 (peer-reviewed). PubMed PMC3970941USC
35.Janib SM, Pastuszka MK, Aluri SR, Folchman-Wagner Z, Hsueh P, Shi P, Lin YA, Cui H, MacKay JA. A quantitative recipe for engineering protein polymer nanoparticles. Polym Chem. 2014 Jan;5(5):1614-1625. PubMed PMC3916011USC
34.Shi P, Lin YA, Pastuszka M, Cui H, MacKay JA. Triggered Sorting and Co-Assembly of Genetically Engineered Protein Microdomains in the Cytoplasm. Adv Mater. 2014 Jan 22;26(3):449-54. PubMed PMC3947098USC
33.Shi P, Aluri SR, Lin YA, Shah M, Edman-Woolcott M, Dhandhukia J, Cui H, MacKay JA. Elastin-based protein polymer nanoparticles carrying drug at both corona and core suppress tumor growth in vivo. J Cont Rel. 2013 Nov 10;171(3):330-8. PubMed PMC3795821USC
32.Shah M, Edman MC, Janga SR, Shi P, Dhandhukia J, Liu S, Louie SG, Rodgers K, MacKay JA, Hamm-Alvarez SF. A rapamycin-binding protein polymer nanoparticle shows potent therapeutic activity in suppressing autoimmune dacryoadenitis in a mouse model of Sjögren's syndrome. J Cont Rel. 2013 Nov 10;171(3):269-79. PubMed PMC3796004USC
31.Dhandhukia J, Weitzhandler I, Wang W, MacKay JA. Switchable Elastin-Like Polypeptides that Respond to Chemical Inducers of Dimerization. Biomacromolecules. 2013 Apr 8; 14(4):976-85. PubMed PMC3721738USC
30.Janib SM, Liu S, Park R, Pastuszka MK, Shi P, Moses A, Orosco M, Lin YA, Cui H, Conti P, Li Z, MacKay JA. Kinetic quantification of protein polymer nanoparticles using non-invasive imaging. Integr Biol. 2013 Jan; 5(1):183-94. PubMed PMC3762326USC
29.Pastuszka MK, Janib SM, Weitzhandler I, Okamoto CT, Hamm-Alvarez SF, MacKay JA. A tunable and reversible platform for the intracellular formation of genetically engineered protein microdomains. Biomacromolecules. 2012 Nov 12; 13(11):3439-44. PubMed PMC3500625USC
28.Aluri SR, Pastuszka MK, Moses AS, MacKay JA. Elastin-like Peptide-Amphiphiles form nanofibers with tunable length. Biomacromolecules. 2012 Sep 10;13(9):2645-54. PubMed PMC3461336USC
27.Shah M, Hsueh PY, Sun G, Chang HY, Janib SM, MacKay JA. Biodegradation of elastin-like polypeptide nanoparticles. Protein Sci. 2012 Jun;21(6):743-50. PubMed PMC3403411USC
26.Sun G, Hsueh P, Janib S, Hamm-Alvarez SF, MacKay JA. Design and cellular internalization of genetically engineered polypeptide nanoparticles displaying adenovirus knob domain. J Cont Rel. 2011 Oct 30; 155(2):218-26. PubMed PMC3196066USC
25.Chen M, McDaniel JR, MacKay JA, Chilkoti, A. Nanoscale Self-Assembly for Delivery of Therapeutics and Imaging Agents. Technol Innov. 2011 Jan 1;13(1):5-25 (peer-reviewed). PubMed PMC3784687Duke
24.MacKay JA, Callahan DJ, FitzGerald KN, Chilkoti A. A quantitative model of the phase behavior of recombinant pH-responsive protein polymers. Biomacromolecules. 2010 Oct; 11(11): 2873-9. PubMed PMC3032028Duke
23.Janib SM, Moses AS, MacKay JA. Imaging and drug delivery using theranostic nanoparticles. Adv Drug Deliv Rev. 2010 Aug 30;62(11):1052-63 (peer-reviewed). PubMed PMC3769170USC
22.Liu W, MacKay JA, Dreher MR, Chen M, McDaniel JR, Simnick AJ, Callahan DJ, Zalutsky MR and Chilkoti A. Injectable intratumoral depot of thermally responsive polypeptide-radionuclide conjugates delays tumor progression in a mouse model. J Cont Rel. 2010 May 21;144(1):2-9. PubMed PMC2862899Duke
21.Pastuszka MK, MacKay JA. Biomolecular engineering of intracellular switches in eukaryotes. J Drug Deliv Sci Technol. 2010 May;20(3):163-169 (peer-reviewed). PubMed PMC3013508USC
20.McDaniel J, MacKay JA, Quiroz F, Chilkoti, A. Recursive Directional Ligation by Plasmid Reconstruction allows Rapid and Seamless Cloning of Oligomeric Genes. Biomacromolecules. 2010 Apr 12;11(4):944-52. PubMed PMC2862688Duke
19.Co-editor, with Zibo Li, Advanced Drug Delivery Reviews issue entitled “Development of theranostic agents that co-deliver therapeutic and imaging agents”, 62(11) 2010.USC
18.MacKay JA, Chen M, McDaniel JR, Liu W, Simnick AJ, Chilkoti A. Self-assembling chimeric polypeptide-doxorubicin conjugate nanoparticles that abolish tumors after a single injection. Nat Mater. 2009 Dec;8(12):993-9. PubMed PMC2862348Duke
17.Gao W, Liu W, MacKay JA, Zalutsky M, Toone E, Chilkoti A. In situ growth of a stoichiometric PEG-like conjugate at a protein’s N-terminus with significantly improved pharmacokinetics. Proc Natl Acad Sci U S A. 2009 Sep 8;106(36):15231-6. PubMed PMID19706892Duke
16.Aluri S, Janib SM, MacKay JA. Environmentally responsive peptides as anticancer drug carriers. Adv Drug Deliv Rev. 2009 Sep 30;61(11):940-52 (peer-reviewed). PubMed PMC2757494USC
15. Wu Y, MacKay JA, McDaniel JR, Chilkoti A, Clark RL. Fabrication of Elastin-Like Polypeptide Nanoparticles for Drug Delivery by Electrospraying. Biomacromolecules. 2009 Jan 12;10(1):19-24. PubMed PMID19072041Duke
14.MacKay JA, Chilkoti A. Temperature sensitive peptides: engineering hyperthermia-directed therapeutics. Int J Hyperthermia. 2008 Sep;24(6):483-95 (peer-reviewed). PubMed PMID18608590Duke
13.MacKay JA, Li W, Huang Z, Huynh G, Dy E, Tihan T, Collins R, Deen DF, Szoka FC Jr. HIV TAT peptide modifies the distribution of liposomes, DNA nanolipoparticles, and transfection following convection enhanced delivery. Mol Ther. 2008 May;16(5):893-900. PubMed PMID18388927UCSF
12. Lim DW, Trabbic-Carlson K, MacKay JA, Chilkoti A. Improved non-chromatographic purification of a recombinant protein by cationic elastin-like polypeptides. Biomacromolecules. 2007 May;8(5):1417-24. PubMed PMID17407348Duke
11.Chilkoti A, Christensen T, MacKay JA. Stimulus responsive elastin biopolymers: Applications in medicine and biotechnology. Curr Opin Chem Biol. 2006 Dec;10(6):652-7 (peer-reviewed). PubMed PMID17055770Duke
10.Huang Z, Guo X, Li W, MacKay JA, Szoka FC Jr. Acid-triggered transformation of diortho ester phosphocholine liposome. J Am Chem Soc. 2006 Jan 11;128(1):60-1. PubMed PMID16390121UCSF
9. Lee CC, MacKay JA, Frechet JM, Szoka FC. Designing dendrimers for biological applications. Nat Biotechnol. 2005 Dec;23(12):1517-26 (peer-reviewed). PubMed PMID16333296UCSF
8. Huang Z, Li W, Mackay JA, Szoka FC Jr. Thiocholesterol-based lipids for ordered assembly of bioresponsive gene carriers. Mol Ther. 2005 Mar;11(3):409-17. PubMed PMID15727937UCSF
7.Krylova IN, Sablin EP, Moore J, Xu RX, Waitt GM, MacKay JA, Juzumiene D, Bynum JM, Madauss K, Montana V, Lebedeva L, Suzawa M, Williams JD, Williams SP, Guy RK, Thornton JW, Fletterick RJ, Willson TM, Ingraham HA. Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1. Cell. 2005 Feb 11;120(3):343-55. PubMed PMID15707893UCSF
6.MacKay JA, Deen DF, Szoka FC Jr. Distribution in brain of liposomes after convection enhanced delivery; modulation by particle charge, particle diameter, and presence of steric coating. Brain Res. 2005 Feb 28;1035(2):139-53, cover. PubMed PMID15722054UCSF
5. Li W, Huang Z, MacKay JA, Grube S, Szoka FC Jr. Low-pH-sensitive poly(ethylene glycol) (PEG)-stabilized plasmid nanolipoparticles: effects of PEG chain length, lipid composition and assembly conditions on gene delivery. J Gene Med. 2005 Jan;7(1):67-79. PubMed PMID15515149UCSF
4.Guo X, MacKay JA, Szoka FC Jr. Mechanism of pH-triggered collapse of phosphatidylethanolamine liposomes stabilized by an ortho ester polyethyleneglycol lipid. Biophys J. 2003 Mar;84(3):1784-95. PubMed PMC1302747UCSF
3.Choi JS, MacKay JA, Szoka FC Jr. Low-pH-sensitive PEG-stabilized plasmid-lipid nanoparticles: preparation and characterization. Bioconjug Chem. 2003 Mar-Apr;14(2):420-9. PubMed PMID12643753UCSF
2. MacKay JA, Szoka FC Jr. HIV TAT protein transduction domain mediated cell binding and intracellular delivery of nanoparticles. J Disp Sci Tech. 2003 (peer-reviewed). 24(3-4): 467-73. PubMed PMID20808712UCSF
1. Martin I, Shastri VP, Padera RF, Yang J, MacKay JA, Langer R, Vunjak-Novakovic G, Freed LE. Selective differentiation of mammalian bone marrow stromal cells cultured on three-dimensional polymer foams. J Biomed Mater Res. 2001 May;55(2):229-35. PubMed PMID11255174MIT